Патология олигодендроглии и когнитивные расстройства при шизофрении
https://doi.org/10.30629/2618-6667-2017-76-77-88
Аннотация
Цель обзора: представить новые литературные данные об участии олигодендроцитов и миелина в когнитивной дисфункции при шизофрении. Материал и метод: систематический обзор литературы. Результаты: настоящий обзор посвящен роли олигодендроцитов и миелина в когнитивных функциях мозга, патологии олигодендроцитов и миелина в мозге при шизофрении, связи нарушений олигодендроцитов и миелина с когнитивной дисфункцией у больных шизофренией и влиянию лечения на олигодендроциты и когнитивные нарушения. Важное значение нарушений структуры и функций олигодендроцитов и миелинизации мозга в патогенезе когнитивных расстройств при шизофрении подтверждены результатами нейровизуализационных, генетических, биохимических и морфометрических исследований мозга больных шизофренией. Заключение: стимуляция олигодендроглиогенеза и миелиногенеза в коре больших полушарий может стать новой стратегией в лечении когнитивных расстройств у больных шизофренией.
Об авторе
Наталия Александровна Уранова
ФГБНУ «Научный центр психического здоровья», Москва
Россия
Россия
доктор медицинских наук, заведующий лабораторией клинической
нейроморфологии
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Рецензия
Для цитирования:
Уранова Н.А. Патология олигодендроглии и когнитивные расстройства при шизофрении. ПСИХИАТРИЯ. 2017;(76):77-88. https://doi.org/10.30629/2618-6667-2017-76-77-88
For citation:
Uranova N. Pathology of oligodendroglia and cognitive impairment in schizophrenia. Psychiatry (Moscow) (Psikhiatriya). 2017;(76):77-88. (In Russ.) https://doi.org/10.30629/2618-6667-2017-76-77-88
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