The aim of the study is to analyze the efficacy and safety of Cereton (choline alfosceratus) therapy in aMCI patients and to determine the influence of the drug on the changes in phosphatidylcholine and sphingomyelin content and activity of sphingomyelinase gene.Materials and methods: the study included 20 аМСI patients. All patients received Cereton one capsule (400 mg) three times a day during 90 days. We conducted the effectiveness of therapy at 0, 45 and 90 day of Cereton treatment with psychometric scales (MMSE, FAB, МDRS, clock drawing test, BNT, test of memorizing 10 words, delayed recall of 10 words). Before therapy (day 0) and at the final visit (90 days) patients were taken blood tests, blood plasma was used for analysis of the content of phospholipids, phosphatidylcholines, sphingomyelins and ceramides, and whole blood for analysis of gene expression.Results: the most аMCI patients had an increased phosphatidylcholine content in blood plasma and increased gene expression of acidic sphingomyelinase after the Cereton treatment.Conclusion: testing the gene expression level, the sphingomyelin metabolism and the phosphatidylcholine content in the treatment of drugs affecting the metabolism of sphingolipids can be used as objective markers of the effectiveness of Cereton therapy (choline alphosceratus) in the treatment of aMCI patients.

The aim of the present research was study premorbid personality organization in forming psychotic symptomatology in HIV-in- fected schizophrenic patients and schizophrenic patients without HIV.Material and methods: forty HIV-infected patients with verified diagnosis of schizophrenia were included into study. Among studied patients were 23 females (58%) and 17 males (42%). Forty patients with schizophrenia without HIV is control group (23 females, 48% and 21 males (52%). The psychopathological are state in all schizophrenic patients were assessed by use the special rating scale (PANSS), Munich personal test. Methods of statistics: the correlation analysis and a principal component analysis.The main results: immunological status of big part inspected HIV-infected schizophrenic patients is according with the AIDS. How- ever, there is not focal neurologic symptomatology, somatic and specific infection pathology in HIV-infected schizophrenic patients. А principal component analysis in HIV-infected schizophrenic patients and schizophrenic patients without HIV is formed meaningful cor- relation between symptoms of psychopathological syndromes. There is the influence of premorbid personality structure on psychotic symptomatology in schizophrenic patients without HIV-infection. However the psychotic symptomatology in HIV-infected schizo- phrenic patients does not depend on premorbid personality structure and depends on HIV-infection. Total part of explain dispersion of principal component analysis in this study was only 41%. However this conformity were received in both research groups. There is rather equal statefulness of psychotic symptomatology in HIV-infected schizophrenic patients and schizophrenic patients without HIV.Conclusion: a high evidence of personality rigidity has an influence on mechanism in T-lymphocyte cytotoxicity in HIV-infected schizophrenic patients.

The aim was to analyze current diagnostic concepts and methodological approaches to the diagnosis in general and forensic psychiatry.Material and methods: the literature data on the diagnosis’ concepts and methods of diagnostic studies in general and forensic psychiatry was reviewed comparatively for the last 50 years (mostly - the last 10 years).Results: the study allowed to present a multifaceted picture of diagnostic concepts and methods (including paraclinical ones) in psychiatry. The ambiguity of scientific views on the diagnostically relevant factors, similarities and differences between the diag- nostic process and the structure of the diagnosis in general and forensic psychiatry were shown. The prospects for development of diagnostic approaches in psychiatry, taking into account achievements of neuroscience and of new guidelines in DSM-5 and ICD-11 (draft) are discussed.Conclusion: the multidimensional analysis of a problem of diagnosis in general and forensic psychiatry is the basis for optimization of the diagnostic process in general and forensic psychiatry, which has medical and social importance.

Background: the Eating Attitude Test (EAT-26) is one of reliable and valid screening instruments to measure disordered eating for general population. There is no relevant Russian version of EAT-26.The aim was to translate EAT-26 with involvement of the expert, to estimate its factorial structure and reliability and to assess an occurrence of risk of eating disorders in non-clinical population of girls.Material and methods: EAT-26 was translated into Russian with the assistance of O.B. Bukhina (USA, clinical psychologist, profes- sional translator). Russian version of EAT-26 was administered to non-clinical sample of 188 female students (19,44 ± 2,15 years old). 32 girls were re-assessed 6-7 week later.Results: the frequency of high EAT scorers (at and above 20) is 11%. The exploratory factor analysis resulted in a four-factor solu- tion that accounted for 63% of the total variance. Three items (15, 19, 26) were excluded because of low or ambiguous factor loading. Four factors (with factor loadings of 0,59 and above) were extracted: «dieting» (7 items, α = 0,92), «bulimia and food preoccupation» (7 items, α = 0,89), «drive for thinness» (6 items, α = 0,87) and «perceived social pressure to eat» (3 items, α = 0,73). These factors demon- strated high test-retest reliability for all scales (0,77-0,88) except some lower level for «bulimia» (0,64). Internal consistency (α = 0,92) and test-retest reliability (R = 0,88) of EAT-total are at high level.Conclusion: available Russian version of EAT-26 may be recommended for research and practical needs.

The aim of the study was to investigate the impact of prolonged wartime psychogenic factors on affective and schizoaffective disorders.Materials and methods: a total of 133 refugees and internally displaced persons with affective and schizoaffective disorders were examined. Clinical-psychopathological, clinical-epidemiological, pathopsychological, and structural-dynamical methods were applied. Results: among the examined persons women were met twice as often, as men. Women with affective disorders made up the ma- jority of the examinees (73,9%). At the same time men were diagnosed with schizoaffective disorders twice as often. The psychogenies were characterized with protracted course and a combination of general and individual wartime psychological traumas. In whole two thirds of phase and attacks had specificities of the clinical picture, reflecting impact and/or content of psychic trauma, however it was not revealed without statistically significant differences depending on the special features of contribution of psychogenic experiences into the clinical picture of mental disorders. Psychogenies made negative impact more often on the course of affective disorder and schizoaffective disorder (67 cases; 50,0%) in the form of greater frequency and length of phases/attacks with some differences inaffective disorder and in schizoaffective disorder.Conclusion: protracted wartime psychogenies has significant and varied impact on the clinical picture and dynamics of affective and schizoaffective disorders.

Aim: to conduct an observational study to assess the experience of the clinical using of modern drug therapy of dementia in aged and to study the effectiveness and safety of the Sermione using in the complex pathogenetic therapy of the dementia in the outpatient gerontopsychiatric practice.Material and methods: in the non-sampling study were included 85 outpatients (29 men and 56 women; median age 72 years) from Alzheimer's disease and associated disorders Department of FSBSI «Mental health research centre» from 2014 to 2016. The patients were taken Sermion (nicergolin) in the complex pathogenetic therapy of the dementia: 46 patients were treated with the acetylcho- linesterase inhibitors (AChEI), 23 patients - memantine and 16 patients were treated with AChEI and memantine (12 cases of early onset of AD, 19 cases with late onset of AD, 36 cases of mixed dementia) as well as for vascular dementia (18 cases). The clinical method and psychometric scales (MMSE, CDT, CGI) used for the diagnosis and assessment of the results Sermion orally treatment in a dose of 30 mg per day. Sermion is a part of the complex dementia therapy. A total duration of Sermion administration treatment was 3 months. Results: the Sermion treated patients have moderate and minimal improvement in 33.3% of EOAD, at 42,1% with LOAD, in 61,1%of mixed dementia cases and in 88.9% vascular dementia cases according to the CGI scale. The clinical improvement was confirmed the data of the psychometric assessment, in particular, with a 1-point increase in MMSE score in Alzheimer’s disease and with 2-points increase in MMSE score in mixed and vascular dementia patients. It is important to note that the improvement or stabilization of the condition in Sermion treated patients was marked with different severity degrees of dementia. We observed the cognitive functioningпсихиатрия 1`2017improving, the reduction of psychopathological symptoms, primarily depressive and behavioral disorders, and confusion. During the Sermion treatment was not observed negative side effects.Conclusions: the use of orally form Sermion is effective and safe in the complex pathogenetic therapy of the dementia Alzheimer's disease, mixed dementia and vascular dementia (AChEI and memantine). The Sermion appointment in the complex antidementia therapy was validated with different severity of dementia and with the non-cognitive neuropsychiatric disorders.

This article is a review of literature dedicated to the problem of stress-induced (psychogenic) depression comorbide to the onset/ exacerbation of schizophrenia or schizophrenia spectrum disorders.

85-years-old history of the Crimean department of psychiatry is presented. Chair was organized in 1920 at the medical faculty of the Crimean university, and in five years was closed. In 1936 it was reopened at the Crimean medical institute and functions to present tense. Her tragic period of German occupation is described, when most employees perished. The results of dissertation researches of schizophrenia are presented by the employees of chair for the last 50.

This publication provides an overview of materials of 24th European Congress of Psychiatry (Madrid, 12-15 March, 2016). Among the topical issues of psychiatry the problem of suicides was considered. Some presentations and communications covered the causes of suicides, its economical burden and new ways of prevention.